Ferroportin: Porovnání verzí

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Verze z 2. 9. 2010, 13:45

Ferroportin je transmembránový protein, který čerpá železo z buněk. Nachází se na povrchu buněk, kde transportuje nebo skladuje železo, například na:

Aktuální výzkumy ukazují, že ferroportin je inhibován hepcidinem, který je hlavním regulátor metabolismu železa v lidském těle.

Podrobnější zdroje

Schimanski LM et al.. In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations.. Blood. 2005, s. 4096–4102. DOI 10.1182/blood-2004-11-4502. PMID 15692071.

Pietrangelo A. The ferroportin disease.. Blood Cells Mol. Dis.. 2004, s. 131–8. DOI 10.1016/j.bcmd.2003.08.003. PMID 14757427.
Robson KJ, Merryweather-Clarke AT, Cadet E, et al.. Recent advances in understanding haemochromatosis: a transition state.. J. Med. Genet.. 2005, s. 721–30. DOI 10.1136/jmg.2004.020644. PMID 15466004.
Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.. Gene. 1994, s. 171–4. DOI 10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al.. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.. Gene. 1997, s. 149–56. DOI 10.1016/S0378-1119(97)00411-3. PMID 9373149.
Donovan A, Brownlie A, Zhou Y, et al.. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.. Nature. 2000, s. 776–81. DOI 10.1038/35001596. PMID 10693807.
Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism.. J. Biol. Chem.. 2000, s. 19906–12. DOI 10.1074/jbc.M000713200. PMID 10747949.
Haile DJ. Assignment of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to human chromosome 2q32 by in situ hybridization.. Cytogenet. Cell Genet.. 2000, s. 328–9. DOI 10.1159/000015522. PMID 10828623.
McKie AT, Marciani P, Rolfs A, et al.. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.. Mol. Cell. 2000, s. 299–309. DOI 10.1016/S1097-2765(00)80425-6. PMID 10882071.
Hartley JL, Temple GF, Brasch MA. DNA cloning using in vitro site-specific recombination.. Genome Res.. 2001, s. 1788–95. DOI 10.1101/gr.143000. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al.. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.. Genome Res.. 2001, s. 422–35. DOI 10.1101/gr.GR1547R. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al.. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.. EMBO Rep.. 2001, s. 287–92. DOI 10.1093/embo-reports/kvd058. PMID 11256614.
Njajou OT, Vaessen N, Joosse M, et al.. A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis.. Nat. Genet.. 2001, s. 213–4. DOI 10.1038/90038. PMID 11431687.
Montosi G, Donovan A, Totaro A, et al.. Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene.. J. Clin. Invest.. 2001, s. 619–23. DOI 10.1172/JCI13468. PMID 11518736.
Press RD. Hemochromatosis caused by mutations in the iron-regulatory proteins ferroportin and H ferritin.. Mol. Diagn.. 2002, s. 347. DOI 10.1054/modi.2001.0060347. PMID 11774199.
Lee PL, Gelbart T, West C, et al.. A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin.. Blood Cells Mol. Dis.. 2003, s. 783–802. DOI 10.1006/bcmd.2001.0445. PMID 11783942.
Rolfs A, Bonkovsky HL, Kohlroser JG, et al.. Intestinal expression of genes involved in iron absorption in humans.. Am. J. Physiol. Gastrointest. Liver Physiol.. 2002, s. G598–607. DOI 10.1152/ajpgi.00371.2001. PMID 11897618.
Thomas C, Oates PS. IEC-6 cells are an appropriate model of intestinal iron absorption in rats.. J. Nutr.. 2002, s. 680–7. PMID 11925460.
Wallace DF, Pedersen P, Dixon JL, et al.. Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis.. Blood. 2002, s. 692–4. DOI 10.1182/blood.V100.2.692. PMID 12091366.
Devalia V, Carter K, Walker AP, et al.. Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3).. Blood. 2002, s. 695–7. DOI 10.1182/blood-2001-11-0132. PMID 12091367.
Roetto A, Merryweather-Clarke AT, Daraio F, et al.. A valine deletion of ferroportin 1: a common mutation in hemochromastosis type 4.. Blood. 2002, s. 733–4. DOI 10.1182/blood-2002-03-0693. PMID 12123233.

Šablona:Pahýl - biochemie

@@ Řádek 1: / Řádek 1: @@
 {{neověřeno}}
-'''Ferroportin''' je [[transmembránový protein]], který čerpá [[železo]] z buněk. Nachází se na povrchu buněk, kde transportuje nebo skladuje [[železo]], například na:{{doplnit zdroj}}
+'''Ferroportin''' je [[transmembránový protein]], který čerpá [[železo]] z buněk. Nachází se na povrchu buněk, kde '''transportuje nebo skladuje''' [[železo]], například na:
 *[[enterocyt|enterocytech]] v [[dvanáctník|dvanáctníku]]{{Fakt/dne|20100831141946}}
@@ Řádek 7: / Řádek 7: @@
 *[[hepatocyt|hepatocytech]]
-Aktuální výzkumy ukazují, že ferroportin je inhibován [[hepcidin|hepcidinem]], který je hlavním regulátor metabolismu [[železo|železa]] v lidském těle.{{doplnit zdroj}}
+Aktuální výzkumy ukazují, že ferroportin je inhibován [[hepcidin|hepcidinem]], který je hlavním regulátor metabolismu [[železo|železa]] v lidském těle.
-em
+[[en:Ferroportin]]
+==Podrobnější zdroje==
+*{{cite journal  | author=Schimanski LM ''et al.'' |title=''In vitro'' functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations. |journal=Blood |volume=105 |issue= 10 |pages= 4096–4102 |year= 2005 |pmid= 15692071|doi=10.1182/blood-2004-11-4502  }}
+*{{cite journal  | author=Pietrangelo A |title=The ferroportin disease. |journal=Blood Cells Mol. Dis. |volume=32 |issue= 1 |pages= 131–8 |year= 2004 |pmid= 14757427 |doi=10.1016/j.bcmd.2003.08.003  }}
+*{{cite journal  | author=Robson KJ, Merryweather-Clarke AT, Cadet E, ''et al.'' |title=Recent advances in understanding haemochromatosis: a transition state. |journal=J. Med. Genet. |volume=41 |issue= 10 |pages= 721–30 |year= 2005 |pmid= 15466004 |doi= 10.1136/jmg.2004.020644  | pmc=1735598 }}
+*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
+*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
+*{{cite journal  | author=Donovan A, Brownlie A, Zhou Y, ''et al.'' |title=Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. |journal=Nature |volume=403 |issue= 6771 |pages= 776–81 |year= 2000 |pmid= 10693807 |doi= 10.1038/35001596 }}
+*{{cite journal  | author=Abboud S, Haile DJ |title=A novel mammalian iron-regulated protein involved in intracellular iron metabolism. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19906–12 |year= 2000 |pmid= 10747949 |doi= 10.1074/jbc.M000713200 }}
+*{{cite journal  | author=Haile DJ |title=Assignment of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to human chromosome 2q32 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 328–9 |year= 2000 |pmid= 10828623 |doi=10.1159/000015522  }}
+*{{cite journal  | author=McKie AT, Marciani P, Rolfs A, ''et al.'' |title=A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. |journal=Mol. Cell |volume=5 |issue= 2 |pages= 299–309 |year= 2000 |pmid= 10882071 |doi=10.1016/S1097-2765(00)80425-6  }}
+*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
+*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
+*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732 }}
+*{{cite journal  | author=Njajou OT, Vaessen N, Joosse M, ''et al.'' |title=A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis. |journal=Nat. Genet. |volume=28 |issue= 3 |pages= 213–4 |year= 2001 |pmid= 11431687 |doi= 10.1038/90038 }}
+*{{cite journal  | author=Montosi G, Donovan A, Totaro A, ''et al.'' |title=Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. |journal=J. Clin. Invest. |volume=108 |issue= 4 |pages= 619–23 |year= 2001 |pmid= 11518736 |doi=10.1172/JCI13468  | pmc=209405  }}
+*{{cite journal  | author=Press RD |title=Hemochromatosis caused by mutations in the iron-regulatory proteins ferroportin and H ferritin. |journal=Mol. Diagn. |volume=6 |issue= 4 |pages= 347 |year= 2002 |pmid= 11774199 |doi=10.1054/modi.2001.0060347  }}
+*{{cite journal  | author=Lee PL, Gelbart T, West C, ''et al.'' |title=A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin. |journal=Blood Cells Mol. Dis. |volume=27 |issue= 5 |pages= 783–802 |year= 2003 |pmid= 11783942 |doi= 10.1006/bcmd.2001.0445 }}
+*{{cite journal  | author=Rolfs A, Bonkovsky HL, Kohlroser JG, ''et al.'' |title=Intestinal expression of genes involved in iron absorption in humans. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=282 |issue= 4 |pages= G598–607 |year= 2002 |pmid= 11897618 |doi= 10.1152/ajpgi.00371.2001  | doi_brokendate=2008-10-14 }}
+*{{cite journal  | author=Thomas C, Oates PS |title=IEC-6 cells are an appropriate model of intestinal iron absorption in rats. |journal=J. Nutr. |volume=132 |issue= 4 |pages= 680–7 |year= 2002 |pmid= 11925460 |doi=  }}
+*{{cite journal  | author=Wallace DF, Pedersen P, Dixon JL, ''et al.'' |title=Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis. |journal=Blood |volume=100 |issue= 2 |pages= 692–4 |year= 2002 |pmid= 12091366 |doi=10.1182/blood.V100.2.692  }}
+*{{cite journal  | author=Devalia V, Carter K, Walker AP, ''et al.'' |title=Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3). |journal=Blood |volume=100 |issue= 2 |pages= 695–7 |year= 2002 |pmid= 12091367 |doi= 10.1182/blood-2001-11-0132 }}
+*{{cite journal  | author=Roetto A, Merryweather-Clarke AT, Daraio F, ''et al.'' |title=A valine deletion of ferroportin 1: a common mutation in hemochromastosis type 4. |journal=Blood |volume=100 |issue= 2 |pages= 733–4 |year= 2002 |pmid= 12123233 |doi=10.1182/blood-2002-03-0693  }}
 {{pahýl - biochemie}}